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In this tutorial, an interdisciplinary team of researchers will describe how to best design and analyze interaction in Virtual and Augmented Reality (VR/AR) systems from different perspectives. Manuela Chessa, an expert in perceptual aspects of human-computer interaction, will discuss how interaction in AR affects our senses, and how misperception issues negatively affect interaction. Several technological solutions to interact in VR and AR will be discussed and, finally, the challenges and opportunities of mixed reality (MR) systems will be analyzed. Fabio Solari, an expert in biologically inspired computer vision, will focus on foveated visual processing for action tasks and on the geometry and calibration of interactive AR. Guido Maiello, an innovative young neuroscientist, will present the link between our eyes and hands in the real world with the aim of improving the design of interaction techniques in VR and AR. Giovanni Maria Farinella, a leading computer vision expert, will discuss first person vision and eg ocentric perception. Dimitri Ognibene, whose research uniquely combines robotics with computational neuroscience and machine learning, will describe how perception is an active process in both human and machines. David Rudrauf, a leading expert in mathematical psychology, will present a computational model to investigate human consciousness in virtual worlds. Overall, this unique panel of multi-disciplinary researchers will delineate a compelling argument in favor of investigating human cognition and perception in the context of AR/VR.